Name | BOSENTAN |
Synonyms | BOSENTAN ro47-0203 Bosentan impurity bosentan , CID 104865 2'-bipyrimidin)-4-yl)-enoxy)( Bosentan (Benzenesulfonamide) benzenesulfonamide,4-(1,1-dimethylethyl)-n-(6-(2-hydroxyethoxy)-5-(2-methoxyph 4-(tert-Butyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulf 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide n-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4-yl]-4-tert-butyl-benzenesulfonamide |
CAS | 147536-97-8 |
EINECS | 643-099-1 |
InChI | InChI=1/C27H29N5O6S/c1-27(2,3)18-10-12-19(13-11-18)39(34,35)32-23-22(38-21-9-6-5-8-20(21)36-4)26(37-17-16-33)31-25(30-23)24-28-14-7-15-29-24/h5-15,33H,16-17H2,1-4H3,(H,30,31,32) |
Molecular Formula | C27H29N5O6S |
Molar Mass | 551.61 |
Density | 1.325±0.06 g/cm3(Predicted) |
Melting Point | 107-110°C |
Boling Point | 742.3±70.0 °C(Predicted) |
Flash Point | 402.754°C |
Solubility | DMSO (Slightly), Methanol (Slightly) |
Vapor Presure | 0mmHg at 25°C |
Appearance | Solid |
Color | White to Pale Yeloow |
pKa | 4.01±0.10(Predicted) |
Storage Condition | -20°C Freezer |
Refractive Index | 1.607 |
Use | Endothelin receptor blocker |
HS Code | 29350090 |
crystallized from acetic acid ethanol, melting point> 250 °c.
diethyl 2- (2-methoxyphenoxy) malonate and pyridine-2-carboxamidine hydrochloride were added to a solution of sodium metal in anhydrous methanol and stirred at room temperature, the treatment gave 5-(2-methoxyphenoxy) -2- (pyridin-2-yl) pyridine-4, 6-= alcohol. The diol and N,N-= isopropyl-N-ethyl amine and phosphorus pentachloride were refluxed together, and the product was extracted with acetic acid ethanol and treated to give 4,6-= chloro-5-(2-methoxyphenoxy)-2-(pyridin-2-yl) pyridine. The compound was dissolved in dimethyl sulfoxide, P-tert-butylbenzenesulfonamide was added, and the reaction was worked up to obtain 4-tert-butyl-N-[6-monochloro-5-(2-methoxyphenoxy) -2-(pyridin-2-yl) pyridin-4-yl] benzenesulfonamide. The benzenesulfonamide was coheated with sodium and ethylene glycol at 110 °c, extracted with ethyl acetate, washed, dried, and concentrated under reduced pressure to give bosentan.
developed by Actelion, Switzerland, was first launched in the United States in 2001. Endothelin receptor antagonists. For the treatment of pulmonary hypertension.